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Marinobufagin-470-42-8

Marinobufagin-470-42-8

Marinobufagin HPLC 98% . CAS#: 470-42-8    . . M.F :C24H32O5 M.W: 400.50

Detailed description

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 HT009697 -----Marinobufagin

analytical standard


 

Synonym:Marinobufagenin;5β-Bufa-20,22-dienolide
Cas Number:470-42-8
Molecular Formula:C24H32O5
Molecular Weight:400.50

 


Chemical Name:(3beta,5beta,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide
Appearance:White powder
Grade:analytical standard
Assay:≥98%(HPLC)
Chemical Family: Bufadienolides compounds
Original:Bufo bufo gargarizans Cantor
Storage temp:2~8°C
Pack Size:20mg; 100mg; 1gram ;10gram
Application:For laboratory research use only



 


 Articles:



1.Binding Of Ouabain And Marinobufagenin Leads To Different Structural Changes In Na,K-ATPase And Depends On The Enzyme Conformation.

Klimanova EA, Petrushanko IY, Mitkevich VA, Anashkina AA, Orlov SN, Makarov AA, Lopina OD.

Abstract


Ion pump, Na,K-ATPase specifically binds cardiotonic steroids (CTS), which leads to inhibition of the enzyme activity and activation of signaling network in the cell. We have studied interaction of Na---Read More.


2.Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists.

Fedorova OVEmelianov IVBagrov KAGrigorova YNWei WJuhasz OFrolova EVMarshall CALakatta EGKonradi AOBagrov AY.

Abstract


OBJECTIVE:

Endogenous cardiotonic steroids, including marinobufagenin (MBG), stimulate vascular synthesis of collagen. Because mineralocorticoid antagonists competitively antagonize effect of cardiotonic steroids on the Na/K-ATPase---Read More.



 

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